Clinical Spotlight
Breast cancer is the most commonly diagnosed, and the second leading cause of cancer-related deaths among women worldwide.1 Hormone receptor-positive (HR+) is the most common type of breast cancer, constituting 75% of all breast cancers, with this frequency increasing in pre-menopausal women.2-4 In HR+ early-stage breast cancer, adjuvant endocrine therapy (ET) has been the standard of care. However, many patients acquire resistance to ET and disease progression eventually occurs.4 In this symposium, the expert faculty address key questions such as which therapies should be considered in patients with high-risk breast cancer to address the inevitable challenges of treatment resistance and how new therapies could potentially be integrated into future treatment strategies. An interactive case presentation will be used to illustrate the differentiated approach to the management of patients with breast cancer in the adjuvant setting.
Module 1: Potential of new targeted agents in high-risk early breast cancer – are we entering a new era?
Prof. Valentina Guarneri describes new strategies that are under evaluation for high-risk early breast cancer, including CDK4/6 inhibitors and immunotherapies. She addresses the importance of baseline assessment and how dynamic risk assessment can inform treatment outcomes.
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Module 2: Panel Discussion
Prof. Christoph Zielinski leads a panel discussion on the relevance of clinical trials assessing CDK4/6 inhibitors as adjuvant therapy, how these treatments can be differentiated and the potential utility of these treatments in the future management of high-risk early breast cancer.
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Module 3: The high-risk early breast cancer patient – how can we apply a differentiated approach in the clinic?
Prof. François-Clément Bidard presents an interactive case study of a patient with early breast cancer. He considers how to tailor adjuvant treatment, the requirements for future therapies, the impact on patient fertility and the need for combination therapy.
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